Faecalibacterium prausnitzii in Eczema

Faecalibacterium prausnitzii is one of the most abundant bacterial species found in healthy adults. It has been consistently reported as one of the main butyrate producers found in the intestine.

What is butyrate and how can it affect eczema sufferers?

Butyrate is produced when bacteria in your gut help your body break down dietary fiber in food. Butyrate is a short chain fatty acid that has been shown to reduce inflammation, relieve gastrointestinal conditions, support the gut barrier and immune system, and may help protect your body against a wide range of diseases.

Faecalibacterium prausnitzii → butyrate → healthy outcome

However, researchers show that a F. prausnitzii subvariant named F. prausnitzii L2-6 might play a pivotal role in patients with Atopic Dermatitis, from onset in childhood to the current day-to-day.

Researchers show that a F. prausnitzii subvariant named  F. prausnitzii L2-6 might play a pivotal role in patients with Atopic Dermatitis, from onset in childhood to the current day-to-day. This Faecalibacterium prausnitzii L2-6 is linked to a reduced production of butyrate.

This dysregulation of the gut microbiome promotes a chronic leaky gut, where toxins continually get into the bloodstream to trigger an overactive Th2 response, an abnormal immune response to skin allergens. 

Faecalibacterium prausnitzii L2-6 → reduced butyrate → disease outcome

 Understanding the complicated, multifactorial nature of eczema and bacteria's role in it's progression can help us better understand strategies for managing healthy outcomes. 
 

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