Improves the look and feel of your skin in 90 days or less.
A skin health breakthrough from over 7 years of research, Defensin™ Probiotic Spray was created by a team of doctors to promote healthy skin.
Probiotic strain Roseomonas mucosa RSM 2015 clinically shown to improve skin health.(1),(2)
9 out of 10 patients achieved clearer, healthier skin in the clinical trial.(1)
Innovated and studied by doctors at the NIH.(1),(2)
(1) Myles, Ian A et al. Sci Transl Med 2020 Sep 9;12(560):eaaz8631. doi: 10.1126/scitranslmed.aaz8631.
(2) Myles, Ian A, et al. JCI Insight. 2018 May 3;3(9):e120608. doi: 10.1172/jci.insight.120608.
Probiotic innovated and tested against placebo by NIH research.(1,2)
(1) Myles, Ian A et al. Sci Transl Med 2020 Sep 9;12(560):eaaz8631. doi: 10.1126/scitranslmed.aaz8631.
(2) Myles, Ian A, et al. JCI Insight. 2018 May 3;3(9):e120608. doi: 10.1172/jci.insight.120608.
Patients saw reduction of itchy, dry, inflamed skin.
Patients achieved clear, healthy skin.
(1) Myles, Ian A et al. Sci Transl Med 2020 Sep 9;12(560):eaaz8631. doi: 10.1126/scitranslmed.aaz8631.
(2) Myles, Ian A, et al. JCI Insight. 2018 May 3;3(9):e120608. doi: 10.1172/jci.insight.120608.
(1) Myles, Ian A et al. Sci Transl Med 2020 Sep 9;12(560):eaaz8631. doi: 10.1126/scitranslmed.aaz8631.
(2) Myles, Ian A, et al. JCI Insight. 2018 May 3;3(9):e120608. doi: 10.1172/jci.insight.120608.
Defensin™ contains a topical probiotic discovered and tested by a team of doctors to soothe itchy, rashy skin. Probiotics are live microorganisms that provide a health benefit when administered in specific amounts.
Our probiotic strain Roseomonas RSM2015 has been shown to be a ceramide producer. Ceramides are important for retaining your skin's moisture and strengthening skin barrier function. Our live probiotic has been proven safe and effective in placebo controlled clinical trials. Academic research has demonstrated that Roseomonas mucosa RSM2015 is the top probiotic strain for protecting and enhancing the skin barrier. In addition, ground cardamom seed soothes itchy skin caused by the overactivation of TRPA1.
Roseomonas mucosa RSM2015, ground cardamom seeds, and sucrose
Probiotics are live microorganisms that provide health benefits when administered in adequate amounts. By definition, probiotics must have a scientifically demonstrated health effect.
In the case of Defensin™ Topical Skin Probiotic, our probiotic ingredient can be matched to two randomized controlled clinical trials that show safety and efficacy in promoting clear, healthy skin. Our probiotic is a one-of-a-kind probiotic strain that is not available generically.
Note: 99% of the "probiotic" topical skincare products are not probiotics at all, rather they are lysates, or probiotic byproducts which are not living.
Buy with confidence - if you're unsatisfied for any reason, return within 90 days, no questions asked, just email us at support@skinesa.com for easy to follow instructions. We offer a 100% hassle-free refund guarantee. Our refund policy here.
We recommended spraying the probiotic ingredients onto the desired areas where you would like healthier skin. For optimal and sustained results, we suggest continuous, every other day use for at least 90 days.
Clinical evidence shows that Roseomonas mucosa RSM2015 promotes healthier skin.
You may see results within a few days, but clinical evidence from clinics shows that you will get the best benefits for your skin following 90 days of every other day of use.
Use warm water to flush it out. If you think your spray bottle has a clog, we suggest taking the top off and placing the tubing (with the nozzle still attached) in a cup of warm water; pump the spray top until water sprays out with ease. Once you're satisfied with the mechanism, place the top back onto the bottle and continue using.
Yes. We suggest using cooled distilled water as the safest option out of an abundance of caution. Filtered, clean water is another option.
No. You should clean out your bottle after every use. We suggest the maximum you should leave the probiotics in water to remain effective is less than 30 minutes.
Yes. However, do not spray in or near the eyes.
We advise consulting with your physician if you are currently taking medications.
There are no known side effects based on the 2 successful clinical trials.
First thing in the morning before your morning routine and/or right before you go to bed at night. Allowing yourself a little time to air dry is ideal.
For best results, we suggest applying lotions at a different part of the day. For example, if you apply Defensin™ at night, apply lotions in the morning. In addition, please be aware that some popular lotions have been shown to kill R. Mucosa RSM2015. Please read more here.
You should receive instant results from itching during the first applications. (This is from the ground cardamom seeds) However, you should experience healthier, clear skin after a few weeks of probiotic application. The best and longest lasting results in clinical trials were achieved after 90 days of every other day application.
We encapsulate probiotics proven safe and effective for promoting skin health in double-blind, placebo-controlled controlled clinical trials.
About the Clinical Trials
University-based, double-blind, placebo-controlled trial measured the effects of our probiotic mixtures in skin health
Peer Reviewed & Published
After passing a rigorous review, our gold standard clinical study was published in JAMA Dermatology — a top-tier, internationally recognized, peer-reviewed American medical journal.
A second study was published in ACTA Dermatology - a prominent European medical journal:
Why It Matters
We are incredibly proud of the evidence-based products we formulate, and we believe clinical studies are the best way to directly measure their impact.
